This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 673737

The "Gliomark" Project

Latest news: Phase II clinical study (Cliomark1) successfully completed. See also here

Validation of blood-brain-barrier permeability as a glioma biomarker by means of the radiotracer 99mTc-tetrofosmin and single-photon emission computer tomography (GLIOMARK)

The objective of GLIOMARK is to clinically validate the permeability of the blood brain barrier (BBB) as an in vivo biomarker for the diagnosis and grading of gliomas. This will be accomplished by means of the radiotracer 99mTc-tetrofosmin (TTF) and the imaging technique Single-Photon Emission Computer Tomography (SPECT).

The outcome of GLIOMARK is a diagnostic kit containing handling/diagnostic instructions and tetrofosmin. The latter has to be reconstituted with 99mTc pertechnetate to yield TTF, which will be used in combination with SPECT.

Gliomas are recognized as a rare tumor disease with poor prognosis. Often computer tomography or magnetic resonance imaging is unable to detect low-grade gliomas or distinguish glioma from other diseases. Hence, brain biopsies are necessary for confirmation of diagnosis and grading of gliomas. Our kit employs TTF/SPECT and enables reliable, fast differential diagnosis and grading of gliomas as non-invasive method. This has an immediate impact on the type and aggressiveness of subsequent therapies.

This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 673737.

The concept of this project was based on the innovative research work by Dr. Andreas Fotopoulos (Professor of Nuclear Medicine, University of Ioannina and University Hospital of Ioannina) and his group over the last decade.

For more information about GLIOMARK please visit the project’s newly released website:

Coaching experiences under Horizon 2020 - SME Instrument Phase 2 [Appointed Coach: Dr I.Arzimanoglou]

"I am pleased to share my experiences from the coaching service received in the frames of our SME Instrument Phase 2 project “GLIOMARK”.Our company, received 6 full days of high-level coaching by Dr. Iordanis Arzimanoglou. His views and strategic advices were highly appreciated and supported our company’s international strategic development for the GLIOMARK project and beyond. Dr Arzimanoglou was able to efficiently evaluate our company’s position in the competitive field of imaging biomarkers and in-vivo diagnostics, to identify our strengths and weaknesses and thus providing tailor-made consultancy that completely fitted our needs and expectations. We strongly recommend Dr Arzimanoglou as a coach in life sciences projects and we would like to thank both our coach and EASME for giving us the opportunity to further expand our horizons.
We fully endorse coaching service for SMEs to be provided on a sectorial basis (in our case biomedical/diagnostic sector) in order to better fit each company’s needs, rather than on a general business consultancy level from experts lacking in-depth knowledge in the relevant sector."


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